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Why Manual Testing Still Matters in Regulated Industries

January 15, 20268 min read

Introduction

In an era of AI and automation, it might seem counterintuitive to advocate for manual testing. Yet in regulated industries—healthcare, automotive, aerospace, pharmaceuticals—manual testing is not just relevant; it is mandatory.

Why Regulations Require Human Verification

Regulatory bodies like the FDA, ISO, and IEC have clear requirements for human oversight in software validation. Here is why:

Audit Trail Requirements

Every test must be traceable to a human tester who verified the result. Automated tests can execute, but a human must review and sign off on the outcomes. This creates accountability and ensures that critical decisions have human judgment behind them.

Edge Case Judgment

Automated tests follow predefined paths. Human testers catch the unexpected—the edge cases that no one anticipated. In medical devices or safety-critical systems, these edge cases can mean the difference between patient safety and harm.

Contextual Understanding

A machine can verify that a button exists. A human can evaluate whether that button makes sense in the workflow, whether the label is clear, whether the placement follows usability best practices.

Industries Where Manual Testing Is Mandatory

Healthcare & Medical Devices

FDA 21 CFR Part 11 requires electronic records to have documented human verification. IEC 62304 mandates human oversight throughout the software lifecycle. Software as Medical Device (SaMD) regulations specifically require human validation of AI-assisted decisions.

Automotive

ISO 26262 for functional safety requires human verification at each Automotive Safety Integrity Level (ASIL). ADAS features—lane keeping, collision avoidance—need human testers to evaluate real-world scenarios.

Pharmaceuticals

GxP compliance demands documented human testing. GAMP 5 guidelines require human validation of computerized systems. Data integrity principles (ALCOA+) assume human verification.

The Right Balance

This is not an argument against automation. Automated tests are essential for regression, performance, and repetitive scenarios. The key is balance:

  • Automate repetitive, deterministic tests
  • Manual test edge cases, usability, and compliance scenarios
  • Human sign-off on all critical test results
  • Conclusion

    In regulated industries, manual testing is not a legacy practice—it is a compliance requirement. Organizations that try to eliminate manual testing entirely will find themselves unprepared for audits and potentially liable for compliance failures.

    The future is not manual versus automated testing. It is knowing when each approach is appropriate and building a quality process that leverages both effectively.

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